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Cross-sectional associations between air pollution and chronic bronchitis : an ESCAPE meta-analysis across five cohorts

Cai, Yutong and Schikowski, Tamara and Adam, Martin and Buschka, Anna and Carsin, Anne-Elie and Jacquemin, Benedicte and Marcon, Alessandro and Sanchez, Margaux and Vierkötter, Andrea and Al-Kanaani, Zaina and Beelen, Rob and Birk, Matthias and Brunekreef, Bert and Cirach, Marta and Clavel-Chapelon, Françoise and Declercq, Christophe and de Hoogh, Kees and de Nazelle, Audrey and Ducret-Stich, Regina E. and Valeria Ferretti, Virginia and Forsberg, Bertil and Gerbase, Margaret W. and Hardy, Rebecca and Heinrich, Joachim and Hoek, Gerard and Jarvis, Debbie and Keidel, Dirk and Kuh, Diana and Nieuwenhuijsen, Mark J. and Ragettli, Martina S. and Ranzi, Andrea and Rochat, Thierry and Schindler, Christian and Sugiri, Dorothea and Temam, Sofia and Tsai, Ming-Yi and Varraso, Raphaëlle and Kauffmann, Francine and Krämer, Ursula and Sunyer, Jordi and Künzli, Nino and Probst-Hensch, Nicole and Hansell, Anna L.. (2014) Cross-sectional associations between air pollution and chronic bronchitis : an ESCAPE meta-analysis across five cohorts. Thorax, Vol. 69, no. 11. pp. 1005-1014.

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Official URL: http://edoc.unibas.ch/dok/A6319187

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Abstract

This study aimed to assess associations of outdoor air pollution on prevalence of chronic bronchitis symptoms in adults in five cohort studies (Asthma-E3N, ECRHS, NSHD, SALIA, SAPALDIA) participating in the European Study of Cohorts for Air Pollution Effects (ESCAPE) project.; Annual average particulate matter (PM10, PM2.5, PMabsorbance, PMcoarse), NO2, nitrogen oxides (NOx) and road traffic measures modelled from ESCAPE measurement campaigns 2008-2011 were assigned to home address at most recent assessments (1998-2011). Symptoms examined were chronic bronchitis (cough and phlegm for ≥3 months of the year for ≥2 years), chronic cough (with/without phlegm) and chronic phlegm (with/without cough). Cohort-specific cross-sectional multivariable logistic regression analyses were conducted using common confounder sets (age, sex, smoking, interview season, education), followed by meta-analysis.; 15 279 and 10 537 participants respectively were included in the main NO2 and PM analyses at assessments in 1998-2011. Overall, there were no statistically significant associations with any air pollutant or traffic exposure. Sensitivity analyses including in asthmatics only, females only or using back-extrapolated NO2 and PM10 for assessments in 1985-2002 (ECRHS, NSHD, SALIA, SAPALDIA) did not alter conclusions. In never-smokers, all associations were positive, but reached statistical significance only for chronic phlegm with PMcoarse OR 1.31 (1.05 to 1.64) per 5 µg/m(3) increase and PM10 with similar effect size. Sensitivity analyses of older cohorts showed increased risk of chronic cough with PM2.5abs (black carbon) exposures.; Results do not show consistent associations between chronic bronchitis symptoms and current traffic-related air pollution in adult European populations.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Air Pollution and Health (Künzli)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli)
UniBasel Contributors:Künzli, Nino and Probst Hensch, Nicole and Schikowski, Tamara and Adam, Martin and Keidel, Dirk and Schindler, Christian and Tsai, Ming
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:British Medical Association
ISSN:0040-6376
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Jan 2015 09:24
Deposited On:09 Jan 2015 09:24

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