Polymorphic receptors: neuronal functions and molecular mechanisms of diversification

Schreiner, Dietmar and Nguyen, Thi-Minh and Scheiffele, Peter. (2014) Polymorphic receptors: neuronal functions and molecular mechanisms of diversification. Current opinion in neurobiology, Vol. 27. pp. 25-30.

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Official URL: http://edoc.unibas.ch/dok/A6319257

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The formation of neuronal circuits is driven by complex developmental programs. A key feature of such programs is the precise spatiotemporal control of cell surface recognition molecules in genetically defined cells. Moreover, epigenetic modifications and alternative splicing processes have emerged that are not genetically predetermined but stochastic in nature. Recent studies have highlighted critical functions of such stochastic processes in neuronal wiring and neuronal self-recognition. In this review, we will illustrate recently identified principles that control the molecular diversity of neuronal cell surface receptors, and the function of such receptors in encoding a dynamic or stable neuronal identity.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Scheiffele)
UniBasel Contributors:Scheiffele, Peter
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Current Biology
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:05 Dec 2014 09:45
Deposited On:05 Dec 2014 09:45

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