Control of asymmetric cell division

Roubinet, Chantal and Cabernard, Clemens. (2014) Control of asymmetric cell division. Current opinion in cell biology, Vol. 31C. pp. 84-91.

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Official URL: http://edoc.unibas.ch/dok/A6308489

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Asymmetric cell division (ACD) is a mechanism to generate cellular diversity and used by prokaryotes and eukaryotes alike. Stem cells in particular rely on ACD to self-renew the stem cell while simultaneously generating a differentiating sibling. It is well established that the differential partitioning of cell fate determinants in the form of RNA and proteins between sibling cells induces changes in cell behavior and fate. Recently, insight into molecular mechanisms has been gained that could explain how centrosomes and centrosome-associated structures such as histones, chromosomes or the primary cilium, segregate asymmetrically. Similarly, many cell types also generate physical asymmetry in the form of sibling cell size differences. Emerging data suggests that spindle-induced cleavage furrow positioning through regulated spindle placement and spindle geometry is insufficient to explain all occurrence of cell-size asymmetry. Instead, asymmetric membrane extension based on asymmetric Myosin localization and cortical remodeling could be a driving force for the generation of physical asymmetry.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Growth and Development (Cabernard)
UniBasel Contributors:Cabernard, Clemens
Item Type:Article, refereed
Article Subtype:Book Review
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:29 Jan 2016 09:14
Deposited On:05 Dec 2014 09:45

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