Signalling through the neurotrophin receptor p75NTR

Dechant, G. and Barde, Y. A.. (1997) Signalling through the neurotrophin receptor p75NTR. Current Opinion in Neurobiology, Vol. 7, H. 3. pp. 413-418.

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Official URL: http://edoc.unibas.ch/dok/A5259531

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Activation specific tyrosine kinase receptors by neurotrophins accounts for the longest known biological actions of the neurotrophins, in particular the promotion of neuronal survival. However, recent studies have revealed that nerve growth factor, the neurotrophin regarded as best understood, also activates a signalling pathway by binding to the neurotrophin receptor p75(NTR). This receptor belongs to the tumor necrosis factor receptor family and lacks intrinsic catalytic activity. The p75(NTR) receptor binds all neurotrophins with nanomolar affinity; however, nerve growth factor seems to be uniquely able to activate it, causing the death of trkA-negative neurons during normal development. Thus, nerve growth factor prevents programmed cell death through its receptor TrkA, but promotes it by signalling through p75(NTR).
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Barde)
UniBasel Contributors:Barde, Yves-Alain
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:21
Deposited On:22 Mar 2012 13:22

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