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Association of ambient air pollution with the prevalence and incidence of COPD

Schikowski, Tamara and Adam, Martin and Marcon, Alessandro and Cai, Yutong and Vierkötter, Andrea and Carsin, Anne Elie and Jacquemin, Benedicte and Al Kanani, Zaina and Beelen, Rob and Birk, Matthias and Bridevaux, Pierre-Olivier and Brunekeef, Bert and Burney, Peter and Cirach, Marta and Cyrys, Josef and De Hoogh, Kees and De Marco, Roberto and De Nazelle, Audrey and Declercq, Christophe and Forsberg, Bertil and Hardy, Rebecca and Heinrich, Joachim and Hoek, Gerard and Jarvis, Debbie and Keidel, Dirk and Kuh, Diane and Kuhlbusch, Thomas and Migliore, Enrica and Mosler, Gioia and Nieuwenhuijsen, Mark J. and Phuleria, Harish and Rochat, Thierry and Schindler, Christian and Villani, Simona and Tsai, Ming-Yi and Zemp, Elisabeth and Hansell, Anna and Kauffmann, Francine and Sunyer, Jordi and Probst-Hensch, Nicole and Krämer, Ursula and Künzli, Nino. (2014) Association of ambient air pollution with the prevalence and incidence of COPD. The European respiratory journal, 44 (3). pp. 614-626.

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Official URL: http://edoc.unibas.ch/dok/A6298954

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Abstract

The role of air pollution in chronic obstructive pulmonary disease (COPD) remains uncertain. The aim was to assess the impact of chronic exposure to air pollution on COPD in four cohorts using the standardised ESCAPE exposure estimates. Annual average particulate matter (PM), nitrogen oxides (NOx) and road traffic exposure were assigned to home addresses using land-use regression models. COPD was defined by NHANES reference equation (forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) less than the lower limit of normal) and the Global Initiative for Chronic Obstructive Lung Disease criterion (FEV1/FVC >0.70) and categorised by severity in non-asthmatics. We included 6550 subjects with assigned NOx and 3692 with PM measures. COPD was not associated with NO2 or PM10 in any individual cohort. In meta-analyses only NO2, NOx, PM10 and the traffic indicators were positively, although not significantly, associated with COPD. The only statistically significant associations were seen in females (COPD prevalence using GOLD: OR 1.57, 95% CI 1.11-2.23; and incidence: OR 1.79, 95% CI 1.21-2.68). None of the principal results were statistically significant, the weak positive associations of exposure with COPD and the significant subgroup findings need to be evaluated in further well standardised cohorts followed up for longer time, and with time-matched exposure assignments.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Air Pollution and Health (Künzli)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Air Pollution and Health (Künzli)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Biostatistics - Frequency Modelling (Schindler)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Society, Gender and Health > Gender and Health (Zemp Stutz)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Former Units within Swiss TPH > Exposure Science (Tsai)
UniBasel Contributors:Schikowski, Tamara and Adam, Martin and Schindler, Christian and Tsai, Ming and Zemp Stutz, Elisabeth and Künzli, Nino
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Munksgaard
ISSN:0903-1936
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:03 May 2018 09:41
Deposited On:07 Nov 2014 08:28

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