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Current understanding of mitochondrial DNA in breast cancer

Radpour, Ramin and Fan, Alex XiuCheng and Kohler, Corina and Holzgreve, Wolfgang and Zhong, Xiao Yan. (2009) Current understanding of mitochondrial DNA in breast cancer. The breast journal, Vol. 15, H. 5. pp. 505-509.

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Official URL: http://edoc.unibas.ch/dok/A6007433

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Abstract

The recent surge in mitochondrial research has been driven by the identification of mitochondria-associated diseases and the role of mitochondria in apoptosis and aging. Mitochondrial DNA (mtDNA) has been proposed to be involved in carcinogenesis because of its high susceptibility to mutations and limited repair mechanisms in comparison to nuclear DNA. As mtDNA lacks introns, it has been suggested that most mutations will occur in coding sequences. The subsequent accumulation of mutations may lead to tumor formation. By virtue of their clonal nature, high copy number and high frequent mutations may provide a powerful molecular biomarker for the detection of cancer. It has been suggested that the extent of mtDNA mutations might be useful in the prognosis of cancer outcome and/or the response to certain therapies. In this review article, we aim to provide a brief summary of our current understanding of mitochondrial genetics and biology, review the mtDNA alterations reported in breast cancer, and offer some perspectives as to the emergence of mtDNA mutations, including their functional consequences in cancer development, diagnostic criteria, and therapeutic implications.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Gynecological Oncology (Zhong)
UniBasel Contributors:Zhong, Xiao Yan
Item Type:Article, refereed
Article Subtype:Book Review
Bibsysno:Link to catalogue
Publisher:Blackwell
ISSN:1075-122X
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:15 Aug 2014 07:16
Deposited On:15 Aug 2014 07:16

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