edoc

Late onset of the serological response against the 18 kDa small heat shock protein of Mycobacterium ulcerans in children

Röltgen, Katharina and Bratschi, Martin W. and Ross, Amanda and Aboagye, Samuel Y. and Ampah, Kobina A. and Bolz, Miriam and Andreoli, Arianna and Pritchard, James and Minyem, Jacques C. and Noumen, Djeunga and Koka, Eric and Um Boock, Alphonse and Yeboah-Manu, Dorothy and Pluschke, Gerd. (2014) Late onset of the serological response against the 18 kDa small heat shock protein of Mycobacterium ulcerans in children. PLoS neglected tropical diseases, Vol. 8, H. 5 , e2904.

[img]
Preview
PDF - Published Version
Available under License CC BY (Attribution).

5Mb

Official URL: http://edoc.unibas.ch/dok/A6271957

Downloads: Statistics Overview

Abstract

A previous survey for clinical cases of Buruli ulcer (BU) in the Mapé Basin of Cameroon suggested that, compared to older age groups, very young children may be less exposed to Mycobacterium ulcerans. Here we determined serum IgG titres against the 18 kDa small heat shock protein (shsp) of M. ulcerans in 875 individuals living in the BU endemic river basins of the Mapé in Cameroon and the Densu in Ghana. While none of the sera collected from children below the age of four contained significant amounts of 18 kDa shsp specific antibodies, the majority of sera had high IgG titres against the Plasmodium falciparum merozoite surface protein 1 (MSP-1). These data suggest that exposure to M. ulcerans increases at an age which coincides with the children moving further away from their homes and having more intense environmental contact, including exposure to water bodies at the periphery of their villages.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Immunology (Pluschke)
UniBasel Contributors:Bratschi, Martin and Pluschke, Gerd
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Public Library of Science
ISSN:1935-2727
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Related URLs:
Identification Number:
Last Modified:31 Dec 2015 10:56
Deposited On:18 Jul 2014 09:10

Repository Staff Only: item control page