Visualizing intermolecular interactions in T cells

Gascoigne, Nicholas R. J. and Ampudia, Jeanette and Clamme, Jean-Pierre and Fu, Guo and Lotz, Carina and Mallaun, Michel and Niederberger, Nathalie and Palmer, Ed and Rybakin, Vasily and Yachi, Pia P. and Zal, Tomasz. (2009) Visualizing intermolecular interactions in T cells. Current topics in microbiology and immunology, Vol. 334. pp. 31-46.

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Official URL: http://edoc.unibas.ch/dok/A6007430

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The use of appropriate fluorescent proteins has allowed the use of FRET microscopy for investigation of intermolecular interactions in living cells. This method has the advantage of both being dynamic and of working at the subcellular level, so that the time and place where proteins interact can be visualized. We have used FRET microscopy to analyze the interactions between the T cell antigen receptor and the coreceptors CD4 and CD8. This chapter reviews data on how these coreceptors are recruited to the immunological synapse, and how they interact when the T cell is stimulated by different ligands.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Transplantation Immunology and Nephrology (Palmer/Steiger)
UniBasel Contributors:Palmer, Ed
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:18 Jul 2014 09:10
Deposited On:18 Jul 2014 09:10

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