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Distribution of beta-lactamases A and B in some groups of Yersinia enterocolitica and their role in resistance

Cornelis, G.. (1975) Distribution of beta-lactamases A and B in some groups of Yersinia enterocolitica and their role in resistance. Journal of General Microbiology, Vol. 91, H. 2. pp. 391-402.

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Official URL: http://edoc.unibas.ch/dok/A5259291

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Abstract

Yersinia enterocolitica W222 (serological group 3) synthesized two different intracellular beta-lactamases, called A and B. Enzyme B was more sensitive than A to inhibition by cloxacillin. The minimum inhibitory concentrations of various beta-lactam antibiotics for strains of Y. enterocolitica of groups 3 and 9 and the effect of cloxacillin on these concentrations suggested differential roles for beta-lactamases of types A anb B in penicillin and cephalosporin resistance. Type B enzymes protected Y. enterocolitica against cephalothin and cephalosporin C, wheras type A enzymes protected very efficiently against carbenicillin. Protection against other beta-lactam antibiotics was exerted by both enzymes. However, while both enzymes readily hydrolysed cephaloridine and showed no crypticity with this substrate, they only conferred a very weak protection against it. This may be because cephaloridine reached its target quickly, before it was degraded. The resistance of strains of Y. enterocolitica from groups I, 2 and I6 was also explicable in terms of a two-enzyme system, whereas strains belonging to group 5b produced only a type B lactamase and were sensitive to carbenicillin.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Molecular Microbiology (Cornelis)
UniBasel Contributors:Cornelis, Guy R.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cambridge University Press
ISSN:0022-1287
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:21
Deposited On:22 Mar 2012 13:22

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