Is Pretreatment with Beta-Blockers Beneficial in Patients with Acute Coronary Syndrome?

Cuculi, F. and Radovanovic, D. and Pedrazzini, G. and Regli, M. and Urban, P. and Stauffer, J. C. and Erne, P.. (2009) Is Pretreatment with Beta-Blockers Beneficial in Patients with Acute Coronary Syndrome? Cardiology, 115 (2). pp. 91-97.

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Official URL: http://edoc.unibas.ch/dok/A6008226

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Objectives: The role of beta-blockers in the treatment of hypertension is discussed controversially and the data showing a clear benefit in acute coronary syndromes (ACS) were obtained in the thrombolysis era. The goal of this study was to analyze the role of pretreatment with beta-blockers in patients with ACS. Methods: Using data from the Acute Myocardial Infarction in Switzerland (AMIS Plus) registry, we analyzed outcomes of patients with beta-blocker pretreatment in whom they were continued during hospitalization (group A), those without beta-blocker pretreatment but with administration after admission (group B) and those who never received them (group C). Major adverse cardiac events defined as composed endpoint of re-infarction and stroke (during hospitalization) and/or in-hospital death were compared between the groups. Results: A total of 24,709 patients were included in the study (6,234 in group A, 12,344 in group B, 6,131 in group C). Patients of group B were younger compared to patients of group A and C (62.5, 67.6 and 68.4, respectively). In the multivariate analysis, odds ratio for major adverse cardiac events was 0.59 (CI 0.47-0.74) for group A and 0.66 (CI 0.55-0.83) for group B, while group C was taken as a reference. Conclusions: beta-Blocker therapy is beneficial in ACS and they should be started in those who are not pretreated and continued in stable patients who had been on chronic beta-blocker therapy before.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Further Research Groups at DBM > Signal Transduction (Resink/Erne)
UniBasel Contributors:Erne, Paul
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Publisher:S. Karger
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:25 Oct 2017 08:55
Deposited On:18 Jul 2014 09:09

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