edoc

Receptor-mediated tumor targeting with radiopeptides. Part 1. General principles and methods

Eberle, Alex N. and Mild, Gabriele. (2009) Receptor-mediated tumor targeting with radiopeptides. Part 1. General principles and methods. Journal of receptors and signal transduction, Vol. 29, H. 1. pp. 1-37.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6007494

Downloads: Statistics Overview

Abstract

Radiolabeled peptides have become important tools for preclinical cancer research, and in nuclear oncology they serve as diagnostic and more recently also as therapeutic agents. In the latter application, radiolabeled peptides represent a distinct sector of the molecular targeting approach, which in many areas of therapy implements the old "magic bullet" concept by specifically directing the therapeutic agent to the site of action. Although in the past few years the development of receptor-mediated targeting for therapy has been confined to some radiolabeled antibodies and to somatostatin/SRIF, research into an increasing number of radiolabeled peptides and their receptors expressed by different tumors will soon lead to a wider use of peptide radiopharmaceuticals. In a consecutive series of six reviews we present a comprehensive overview of the literature on receptor-mediated tumor targeting with the different radiopeptides currently studied. Part 1 summarizes the concepts and methods of radiopeptide targeting, the selection of radioisotopes, chelators, the criteria of peptide ligand development and some general aspects of diagnostic and therapeutic application of peptide radiopharmaceuticals.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel
UniBasel Contributors:Eberle, Alex N.
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Marcel Dekker
ISSN:0197-5110
Note:Publication type according to Uni Basel Research Database: Journal item
Related URLs:
Identification Number:
Last Modified:18 Jul 2014 09:09
Deposited On:18 Jul 2014 09:09

Repository Staff Only: item control page