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Digital PCR: a powerful new tool for noninvasive prenatal diagnosis?

Zimmermann, Bernhard G. and Grill, Simon and Holzgreve, Wolfgang and Zhong, Xiao Yan and Jackson, Laird G. and Hahn, Sinuhe. (2008) Digital PCR: a powerful new tool for noninvasive prenatal diagnosis? Prenatal diagnosis, Vol. 28, H. 12. pp. 1087-1093.

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Official URL: http://edoc.unibas.ch/dok/A6007582

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Abstract

Recent reports have indicated that digital PCR may be useful for the noninvasive detection of fetal aneuploidies by the analysis of cell-free DNA and RNA in maternal plasma or serum. In this review we provide an insight into the underlying technology and its previous application in the determination of the allelic frequencies of oncogenic alterations in cancer specimens. We also provide an indication of how this new technology may prove useful for the detection of fetal aneuploidies and single gene Mendelian disorders.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Prenatal Medicine (Hahn)
03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Gynecological Oncology (Zhong)
UniBasel Contributors:Zhong, Xiao Yan and Hahn, Sinuhe
Item Type:Article, refereed
Article Subtype:Book Review
Bibsysno:Link to catalogue
Publisher:Wiley
ISSN:0197-3851
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:20 Jun 2014 07:56
Deposited On:20 Jun 2014 07:56

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