Genes controlling spread of breast cancer to lung "gang of 4"

Eltarhouny, S. A. and Elsawy, W. H. and Radpour, R. and Hahn, S. and Holzgreve, W. and Zhong, X. Y.. (2008) Genes controlling spread of breast cancer to lung "gang of 4". Experimental oncology, Vol. 30, H. 2. pp. 91-95.

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Official URL: http://edoc.unibas.ch/dok/A6007618

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Cancer-related mortality is caused in a large part by the metastasis of primary tumor. Each cancer has a particular way of spreading cancerous cells. Recently, genetic and pharmacological analysis identified the set of genes, such as epidermal growth factor receptor ligand epiregulin (EREG), cyclooxygenase-2 (COX2) and matrix metalloproteinases 1 and 2 (MMP-1 and MMP-2) that have been found to be associated with metastasis of breast cancer to lung. Inhibition of EGFR and COX2 could minimize lung metastasis of breast cancer in a clinical setting. In this review, we summarized the current knowledge on EREG, COX2, MMP-1 and MMP-2 in tumor development and metastasis.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Prenatal Medicine (Hahn)
03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Gynecological Oncology (Zhong)
UniBasel Contributors:Zhong, Xiao Yan and Hahn, Sinuhe
Item Type:Article, refereed
Article Subtype:Book Review
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:04 Sep 2015 14:31
Deposited On:20 Jun 2014 07:56

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