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Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors

Insabato, Luigi and Amelio, Ivano and Quarto, Maria and Zannetti, Antonella and Tolino, Fabio and de Mauro, Gaia and Cerchia, Laura and Riccio, Patrizia and Baumhoer, Daniel and Condorelli, Gerolama and Terracciano, Luigi and de Franciscis, Vittorio. (2009) Elevated expression of the tyrosine phosphatase SHP-1 defines a subset of high-grade breast tumors. Oncology, 77 (6). pp. 378-384.

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Official URL: http://edoc.unibas.ch/dok/A6008258

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Abstract

Objectives: Protein tyrosine phosphatases are key regulators of intracellular signaling that contribute to determining cancer cell growth, which thus makes them attractive targets for therapeutic and diagnostic agents. SHP-1 phosphotyrosine phosphatase is rarely expressed in epithelial tumor cells, but expression has been found in several breast cancer cell lines and tumors. To determine the potential significance of SHP-1 as a prognostic marker in the clinical setting, we examined SHP-1 protein expression in breast tumors. Methods: We analyzed SHP-1 expression by immunohistochemistry in a breast tissue microarray composed of 2,081 cores, either alone or in combination with known prognostic markers. Results: Our data showed that SHP-1 expression was confined to a well-defined subset of high-grade tumors characterized by unique biological parameters. SHP-1 expression correlated directly with expression of the tyrosine kinase receptor HER-2 and inversely with expression of the estrogen receptor, while it was weakly associated with Bcl-2 expression. Conclusions: Levels of SHP-1 were correlated with conventional pathologic parameters of tumor aggressiveness and were associated with reduced patient survival, suggesting that elevated expression of SHP-1 is a common molecular abnormality in a defined subset of breast tumors and might be used in routine diagnosis to identify patients with high-risk tumors.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Molekulare Pathologie (Terracciano)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Molekulare Pathologie (Terracciano)
UniBasel Contributors:Terracciano, Luigi M.
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Karger
ISSN:0030-2414
e-ISSN:1423-0232
Note:Publication type according to Uni Basel Research Database: Journal item
Language:English
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Last Modified:25 Oct 2017 07:06
Deposited On:20 Jun 2014 07:55

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