edoc

[Prophylactic mastectomy in women at high risk for breast cancer: indications and options]

Scheufler, O. and Fritschen, U.. (2008) [Prophylactic mastectomy in women at high risk for breast cancer: indications and options]. Handchirurgie, Mikrochirurgie, Plastische Chirurgie, Jg. 40. pp. 239-247.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6007653

Downloads: Statistics Overview

Abstract

In women at high-risk for breast cancer, bilateral prophylactic mastectomy achieves a risk reduction of up to 95 percent. Provided that proper indications are adhered to and informed consent has been obtained, prophylactic mastectomy can be performed starting at the age of 25 years. As an option, in BRCA1/2 mutation carriers with hereditary breast and ovarian cancer, bilateral prophylactic ovarectomy and salpingectomy reduce the risk of breast cancer by 50 percent and the risk of ovarian cancer by 90 percent. In women of at least 35 years of age and without wish for child bearing, this means of surgical prevention is often suggested at present. The database on chemoprevention in premenopausal high-risk women remains to be defined and procedures are currently advised in conjunction with clinical trials only. As opposed to more radical ablative techniques, we favour subcutaneous mastectomy as a prophylactic means in women at high risk for breast cancer. It combines oncological safety and excellent aesthetic results if performed with the correct surgical technique. Both aspects are of fundamental importance to the often young and still healthy women with this indication who are confronted with the difficult decision for or against a prophylactic mastectomy.
Faculties and Departments:03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Bewegungsapparat und Integument > Plastische, rekonstruktive, ästhetische und Handchirurgie (Schaefer)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Bewegungsapparat und Integument > Plastische, rekonstruktive, ästhetische und Handchirurgie (Schaefer)
UniBasel Contributors:Scheufler, Oliver
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Georg Thieme
ISSN:0722-1819
Note:Publication type according to Uni Basel Research Database: Journal item
Related URLs:
Identification Number:
Last Modified:20 Jun 2014 07:55
Deposited On:20 Jun 2014 07:55

Repository Staff Only: item control page