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Effects of acidogenic diet forms on musculoskeletal function

Jehle, Sigrid and Krapf, Reto. (2010) Effects of acidogenic diet forms on musculoskeletal function. Journal of nephrology, Vol. 23, H. 16 , S77-S84.

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Official URL: http://edoc.unibas.ch/dok/A6007332

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Abstract

Chronic metabolic acidosis exerts well-characterized consequences on musculoskeletal function, including physicochemical dissolution of bone with calcium loss from bone, cellular effects on osteoblasts and osteoclasts and disturbed bone matrix mineralization. These mechanisms are responsible for the acidotic bone phenotype with features of both osteoporosis and osteomalacia. In addition, loss of muscle mass, sarcopenia and negative nitrogen balance are consequences of metabolic acidosis. It is becoming increasingly clear that these effects also occur as a consequence of the diet-induced acid loads characteristic of modern diets. Interventional, short- and long-term studies suggest that the result of neutralizing the diet-induced acid loads is skeletal calcium retention, decreased bone resorption and increases in bone mineral density, suggesting that such an intervention may have an important potential to prevent osteoporosis.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Allgemeine innere Medizin Bruderholz (Krapf)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Ehemalige Einheiten Medizinische Fächer (Klinik) > Allgemeine innere Medizin Bruderholz (Krapf)
UniBasel Contributors:Krapf, Reto
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Wichtig
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:20 Jun 2014 07:55
Deposited On:20 Jun 2014 07:55

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