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Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity

Heck, Angela and Fastenrath, Matthias and Ackermann, Sandra and Auschra, Bianca and Bickel, Horst and Coynel, David and Gschwind, Leo and Jessen, Frank and Kaduszkiewicz, Hanna and Maier, Wolfgang and Milnik, Annette and Pentzek, Michael and Riedel-Heller, Steffi G. and Ripke, Stephan and Spalek, Klara and Sullivan, Patrick and Vogler, Christian and Wagner, Michael and Weyerer, Siegfried and Wolfsgruber, Steffen and de Quervain, Dominique J.-F. and Papassotiropoulos, Andreas. (2014) Converging genetic and functional brain imaging evidence links neuronal excitability to working memory, psychiatric disease, and brain activity. Neuron, 81 (5). pp. 1203-1213.

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Official URL: http://edoc.unibas.ch/dok/A6233688

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Abstract

Working memory, the capacity of actively maintaining task-relevant information during a cognitive task, is a heritable trait. Working memory deficits are characteristic for many psychiatric disorders. We performed genome-wide gene set enrichment analyses in multiple independent data sets of young and aged cognitively healthy subjects (n = 2,824) and in a large schizophrenia case-control sample (n = 32,143). The voltage-gated cation channel activity gene set, consisting of genes related to neuronal excitability, was robustly linked to performance in working memory-related tasks across ages and to schizophrenia. Functional brain imaging in 707 healthy participants linked this gene set also to working memory-related activity in the parietal cortex and the cerebellum. Gene set analyses may help to dissect the molecular underpinnings of cognitive dimensions, brain activity, and psychopathology.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Molekulare Neurowissenschaften (Papassotiropoulos)
05 Faculty of Science > Departement Biozentrum > Services Biozentrum > Life Sciences Training Facility (Papassotiropoulos)
07 Faculty of Psychology
07 Faculty of Psychology > Departement Psychologie
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Molecular Psychology (Papassotiropoulos)
UniBasel Contributors:Gschwind, Leo and Papassotiropoulos, Andreas and Vogler, Christian and Auschra, Bianca and de Quervain, Dominique J.-F. and Heck, Angela and Fastenrath, Matthias and Coynel, David and Milnik, Annette
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cell Press
ISSN:0896-6273
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:02 Nov 2018 17:03
Deposited On:23 May 2014 08:34

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