edoc

Motor-circuit communication matrix from spinal cord to brainstem neurons revealed by developmental origin

Pivetta, Chiara and Esposito, Maria Soledad and Sigrist, Markus and Arber, Silvia. (2014) Motor-circuit communication matrix from spinal cord to brainstem neurons revealed by developmental origin. Cell, Vol. 156, H. 3. pp. 537-548.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6254501

Downloads: Statistics Overview

Abstract

Accurate motor-task execution relies on continuous comparison of planned and performed actions. Motor-output pathways establish internal circuit collaterals for this purpose. Here we focus on motor collateral organization between spinal cord and upstream neurons in the brainstem. We used a newly developed mouse genetic tool intersectionally with viruses to uncover the connectivity rules of these ascending pathways by capturing the transient expression of neuronal subpopulation determinants. We reveal a widespread and diverse network of spinal dual-axon neurons, with coincident input to forelimb motor neurons and the lateral reticular nucleus (LRN) in the brainstem. Spinal information to the LRN is not segregated by motor pool or neurotransmitter identity. Instead, it is organized according to the developmental domain origin of the progenitor cells. Thus, excerpts of most spinal information destined for action are relayed to supraspinal centers through exquisitely organized ascending connectivity modules, enabling precise communication between command and execution centers of movement.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)
09 Associated Institutions > Friedrich Miescher Institut FMI
UniBasel Contributors:Arber, Silvia and Pivetta, Chiara and Esposito, Maria Soledad and Sigrist, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Cell Press
ISSN:0092-8674
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:18 Jul 2014 09:10
Deposited On:23 May 2014 08:34

Repository Staff Only: item control page