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Phosphatidylinositol 3-kinase signaling in thymocytes : the need for stringent control

Fayard, Elisabeth and Moncayo, Gerald and Hemmings, Brian A. and Holländer, Georg A.. (2010) Phosphatidylinositol 3-kinase signaling in thymocytes : the need for stringent control. Science signaling, Vol. 3, H. 135 , re5.

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Official URL: http://edoc.unibas.ch/dok/A6007619

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Abstract

The thymus serves as the primary site for the lifelong formation of new T lymphocytes; hence, it is essential for the maintenance of an effective immune system. Although thymocyte development has been widely studied, the mechanisms involved are incompletely defined. A comprehensive understanding of the molecular events that control regular thymocyte development will not only shed light on the physiological control of T cell differentiation but also probably provide insight into the pathophysiology of T cell immunodeficiencies, the molecular basis that underpins autoimmunity, and the mechanisms that instigate the formation of T cell lymphomas. Phosphatidylinositol 3-kinases (PI3Ks) play a critical role in thymocyte development, although not all of their downstream mediators have yet been identified. Here, we discuss experimental evidence that argues for a critical role of the PI3K-phosphoinositide-dependent protein kinase (PDK1)-protein kinase B (PKB) signaling pathway in the development of both normal and malignant thymocytes, and we highlight molecules that can potentially be targeted therapeutically.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Children's Hospital > Pediatric Immunology (Holländer)
UniBasel Contributors:Holländer, Georg
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:American Association for the Advancement of Science
ISSN:1937-9145
Note:Publication type according to Uni Basel Research Database: Journal item
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Last Modified:23 May 2014 08:33
Deposited On:23 May 2014 08:33

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