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Nonadherence with ambulatory saliva sampling is associated with biased salivary testosterone estimates

Moeller, Julian and Lieb, Roselind and Meyer, Andrea H. and Quack Loetscher, Katharina and Krastel, Bettina and Meinlschmidt, Gunther. (2014) Nonadherence with ambulatory saliva sampling is associated with biased salivary testosterone estimates. Psychoneuroendocrinology, 44. pp. 13-19.

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Official URL: http://edoc.unibas.ch/dok/A6243391

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Abstract

Nonadherence with scheduled saliva sampling, as encount ered in ambulatory settings, can bias the estimation of sa livary cortisol concentrations. This study is the first to estimate if such nonadherence is also associated with bia sed salivary testosterone concentration estimates. ; Using a standard ambulatory saliva-sampling protocol, we instructed pregnant women to collect saliva samples on two consecutive days at awakening, 1100h, 1500h, 2000h, and 2200h. We estimated testosterone concentrations in the saliva samples and participants' actual sampling times with an electronic medication event-monitoring system. We classified a saliva sample as adherent if it was sampled within a specific time window relative to its scheduled sampling time. We used a mixed-model analysis to distinguish between trait (number of adherent saliva samples per participant) and state (adherence status of a specific sample) adherence. ; We included 60 pregnant women in this study. Seventy-five percent (448 of 600) of the scheduled samples indicated adherence with the sampling schedule. Participants' trait adherence was associated with their diurnal profiles of salivary testosterone estimates; that is, adherent participants had higher salivary testosterone estimates compared with nonadherent participants, F(1,58)=5.41, p=0.023, Cohen's d= 0.67. The state adherence of a sample was associated with the salivary testosterone estimate of the related sample, F(1,469)=4.48, p=0.035, Cohen's d=0.20, with delayed sampling associated with lower salivary testosterone estimates. ; The results suggest that common ambulatory nonadherence with scheduled saliva sampling is associated with biased salivary testosterone estimates. They will inform further studies estimating salivary testosterone with ambulatory saliva-sampling designs and highlight the relevance of strategies to improve or confirm adherence, beyond routinely used instructions
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Klinische Psychologie und Epidemiologie (Lieb)
UniBasel Contributors:Lieb, Roselind and Meyer, Andrea Hans and Möller, Julian and Meinlschmidt, Gunther
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0306-4530
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:10 Jan 2019 18:22
Deposited On:23 May 2014 08:33

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