The needle length of bacterial injectisomes is determined by a molecular ruler

Journet, Laure and Agrain, Céline and Broz, Petr and Cornelis, Guy R.. (2003) The needle length of bacterial injectisomes is determined by a molecular ruler. Science, 302, No. 5651. pp. 1757-1760.

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Official URL: http://edoc.unibas.ch/dok/A5259157

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Size determination represents a fundamental requirement for multicomponent biological structures. Some pathogenic bacteria possess a weapon derived from the flagellum. Like the flagellum, this type-III secretion apparatus, called the injectisome, has a transmembrane basal body, but the external component is a needle-like structure instead of a hook and a filament. Here, we provide evidence that the length of this needle is determined by the size of a protein, YscP, acting as a molecular ruler.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Infection Biology
05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Molecular Microbiology (Cornelis)
UniBasel Contributors:Broz, Petr and Cornelis, Guy R.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Association for the Advancement of Science
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2013 08:44
Deposited On:22 Mar 2012 13:21

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