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Expression of the Rai (Shc C) adaptor protein in the human enteric nervous system

Villanacci, V. and Bassotti, G. and Ortensi, B. and Fisogni, S. and Cathomas, G. and Maurer, C. A. and Galletti, A. and Salerni, B. and Pelicci, G.. (2008) Expression of the Rai (Shc C) adaptor protein in the human enteric nervous system. Neurogastroenterology and motility, Vol. 20, H. 3. pp. 206-212.

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Official URL: http://edoc.unibas.ch/dok/A6003462

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Abstract

The adaptor protein Rai (ShcC/N-Shc) is almost exclusively present in the nervous system, although little is documented about its expression in the gut and the enteric nervous system (ENS). As Rai is a physiological substrate of Ret, an important factor for the development of ENS, we have evaluated the expression of Rai in the ENS in various segments of the human gastrointestinal tract. The expression of Rai was assessed by immunohistochemistry in disease-free human gut samples (oesophagus, stomach, small bowel and colon) obtained from subjects undergoing surgical procedures. Rai was not expressed in the epithelia or lymphoid tissue, whereas a moderate level of expression was observed in the endothelial cells of blood vessels and on the outer membrane of smooth muscle cells in both the muscularis mucosae and the muscularis propria. In the ENS, strong positivity was observed only in enteric glial cells, overlapping with GFAP and S100. In conclusion, Rai is expressed in the human gut, especially in the enteric glial cells. We conclude that Rai may provide an additional marker for this cell type.
Faculties and Departments:03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Innere Organe
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Innere Organe
03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie Baselland > Allgemeine und spezielle Pathologie (Cathomas)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie Baselland > Allgemeine und spezielle Pathologie (Cathomas)
UniBasel Contributors:Cathomas, Gieri and Maurer, Christoph A.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Blackwell
ISSN:1350-1925
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:12 Jan 2016 14:37
Deposited On:25 Apr 2014 08:01

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