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Epigenetic therapy for breast cancer

Cai, Feng-Feng and Kohler, Corina and Zhang, Bei and Wang, Ming-Hong and Chen, Wei-Jie and Zhong, Xiao-Yan. (2011) Epigenetic therapy for breast cancer. International journal of molecular sciences, Vol. 12, H. 7. pp. 4465-4487.

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Official URL: http://edoc.unibas.ch/dok/A6005377

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Abstract

Both genetic and epigenetic alterations can control the progression of cancer. Genetic alterations are impossible to reverse, while epigenetic alterations are reversible. This advantage suggests that epigenetic modifications should be preferred in therapy applications. DNA methyltransferases and histone deacetylases have become the primary targets for studies in epigenetic therapy. Some DNA methylation inhibitors and histone deacetylation inhibitors are approved by the US Food and Drug Administration as anti-cancer drugs. Therefore, the uses of epigenetic targets are believed to have great potential as a lasting favorable approach in treating breast cancer.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Gynecological Oncology (Zhong)
UniBasel Contributors:Zhong, Xiao Yan
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Molecular Diversity Preservation International
ISSN:1422-0067
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:27 Mar 2014 13:13
Deposited On:27 Mar 2014 13:13

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