edoc

Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis

Lu, B. C. and Cebrian, C. and Chi, X. and Kuure, S. and Kuo, R. and Bates, C. M. and Arber, S. and Hassell, J. and MacNeil, L. and Hoshi, M. and Jain, S. and Asai, N. and Takahashi, M. and Schmidt-Ott, K. M. and Barasch, J. and D'Agati, V. and Costantini, F.. (2009) Etv4 and Etv5 are required downstream of GDNF and Ret for kidney branching morphogenesis. Nature Genetics, Vol. 41, H. 12. pp. 1295-1302.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A5259062

Downloads: Statistics Overview

Abstract

Glial cell line-derived neurotrophic factor signaling through the Ret receptor tyrosine kinase is crucial for ureteric bud branching morphogenesis during kidney development, yet few of the downstream genes are known. Here we show that the ETS transcription factors Etv4 and Etv5 are positively regulated by Ret signaling in the ureteric bud tips. Mice lacking both Etv4 alleles and one Etv5 allele show either renal agenesis or severe hypodysplasia, whereas kidney development fails completely in double homozygotes. We identified several genes whose expression in the ureteric bud depends on Etv4 and Etv5, including Cxcr4, Myb, Met and Mmp14. Thus, Etv4 and Etv5 are key components of a gene network downstream of Ret that promotes and controls renal branching morphogenesis.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)
UniBasel Contributors:Arber, Silvia
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publ
ISSN:1061-4036
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:20
Deposited On:22 Mar 2012 13:21

Repository Staff Only: item control page