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Neuronal cell type-specific alternative splicing is regulated by the KH domain protein SLM1

Iijima, Takatoshi and Iijima, Yoko and Witte, Harald and Scheiffele, Peter. (2014) Neuronal cell type-specific alternative splicing is regulated by the KH domain protein SLM1. Journal of cell biology, Vol. 204, H. 3. S. 331-342.

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Official URL: http://edoc.unibas.ch/dok/A6223539

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Abstract

The unique functional properties and molecular identity of neuronal cell populations rely on cell type-specific gene expression programs. Alternative splicing represents a powerful mechanism for expanding the capacity of genomes to generate molecular diversity. Neuronal cells exhibit particularly extensive alternative splicing regulation. We report a highly selective expression of the KH domain-containing splicing regulators SLM1 and SLM2 in the mouse brain. Conditional ablation of SLM1 resulted in a severe defect in the neuronal isoform content of the polymorphic synaptic receptors neurexin-1, -2, and -3. Thus, cell type-specific expression of SLM1 provides a mechanism for shaping the molecular repertoires of synaptic adhesion molecules in neuronal populations in vivo.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Scheiffele)
UniBasel Contributors:Scheiffele, Peter
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Rockefeller University Press
ISSN:0021-9525
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:31 Dec 2015 10:55
Deposited On:27 Mar 2014 13:13

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