Migraine, triptans, and the risk of developing rosacea : a population-based study within the United Kingdom

Spoendlin, Julia and Voegel, Johannes J. and Jick, Susan S. and Meier, Christoph R.. (2013) Migraine, triptans, and the risk of developing rosacea : a population-based study within the United Kingdom. Journal of the American Academy of Dermatology, Vol. 69, H. 3. pp. 399-406.

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Official URL: http://edoc.unibas.ch/dok/A6223290

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Rosacea is a common skin disease, involving neurogenic inflammation and neurovascular dysregulation. Migraine has been associated with vascular changes and sterile inflammation. The 2 diseases have been associated over decades, but evidence is scarce. Triptans have vasoconstricting and antiinflammatory properties, but a potential impact of this drug class on rosacea remains uninvestigated.; We sought to analyze the association between migraine or triptan exposure and the risk of developing rosacea within the United Kingdom.; We conducted a case-control study using the United Kingdom-based General Practice Research Database. We identified patients with incident rosacea between 1995 and 2009 (cases), and matched 1 rosacea-free control subject to each case. We compared the prevalence of diagnosed migraine and exposure to triptans before the first-time rosacea diagnosis between cases and controls using multivariate conditional logistic regression.; Among 53,927 cases and 53,927 controls, we observed a small overall association between rosacea and migraine in women (adjusted odds ratio 1.22, 95% confidence interval 1.16-1.29), but not in men. This effect was somewhat more distinct in female migraineurs aged 50 to 59 years (odds ratio 1.36, 95% confidence interval 1.21-1.53). Female triptan users also revealed slightly increasing risk estimates with increasing age, with the highest odds ratio of 1.66 (95% confidence interval 1.30-2.10) in women aged 60 years or older.; This is a retrospective case-control study, for which a certain degree of bias and confounding cannot be ruled out.; We observed a slightly increased risk for female migraineurs to develop rosacea, particularly in women with severe migraine aged 50 years or older.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Clinical Pharmacy (Meier)
UniBasel Contributors:Meier, Christoph R. and Spoendlin, Julia
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:27 Mar 2014 13:12
Deposited On:27 Mar 2014 13:12

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