edoc

Metformin and the risk of endometrial cancer: a case-control analysis

Becker, Claudia and Jick, Susan S. and Meier, Christoph R. and Bodmer, Michael. (2013) Metformin and the risk of endometrial cancer: a case-control analysis. Gynecologic oncology, Vol. 129, H. 3. pp. 565-569.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6223292

Downloads: Statistics Overview

Abstract

To explore the risk of endometrial cancer in relation to metformin and other antidiabetic drugs.; We conducted a case-control analysis to explore the association between use of metformin and other antidiabetic drugs and the risk of endometrial cancer using the UK-based General Practice Research Database (GPRD). Cases were women with an incident diagnosis of endometrial cancer, and up to 6 controls per case were matched in age, sex, calendar time, general practice, and number of years of active history in the GPRD prior to the index date. Odds ratios (ORs) with 95% confidence intervals (95% CI) were calculated and results were adjusted by multivariate logistic regression analyses for BMI, smoking, a recorded diagnosis of diabetes mellitus, and diabetes duration.; A total of 2554 cases with incident endometrial cancer and 15,324 matched controls were identified. Ever use of metformin compared to never use of metformin was not associated with an altered risk of endometrial cancer (adj. OR 0.86, 95% CI 0.63-1.18). Stratified by exposure duration, neither long-term (≥25 prescriptions) use of metformin (adj. OR 0.79, 95% CI 0.54-1.17), nor long-term use of sulfonylureas (adj. OR 0.96, 95% CI 0.65-1.44), thiazolidinediones (≥15 prescriptions; adj. OR 1.22, 95% CI 0.67-2.21), or insulin (adj. OR 1.05 (0.79-1.82) was associated with the risk of endometrial cancer.; Use of metformin and other antidiabetic drugs were not associated with an altered risk of endometrial cancer.
Faculties and Departments:05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Klinische Pharmazie/Spitalpharmazie (Meier)
UniBasel Contributors:Meier, Christoph R.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0090-8258
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:27 Mar 2014 13:12
Deposited On:27 Mar 2014 13:12

Repository Staff Only: item control page