edoc

Immunomodulatory effects of aerobic training in obesity

Nickel, Thomas and Hanssen, Henner and Emslander, Ingrid and Drexel, Verena and Hertel, Gernot and Schmidt-Trucksäss, Arno and Summo, Claudia and Sisic, Zeljka and Lambert, Marius and Hoster, Eva and Halle, Martin and Weis, Michael. (2011) Immunomodulatory effects of aerobic training in obesity. Mediators of inflammation, 2011. p. 308965.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6003475

Downloads: Statistics Overview

Abstract

Physical inactivity and obesity are independent risk factors for atherosclerosis. We analyzed the immunomodulatory capacity of 10-week intensified exercise training (ET) in obese and lean athletes. Markers of the innate immune response were investigated in obese (ONE: ET≤40 km/week) and lean athletes (LNE: ET≤40 km/week and LE: ET≥55 km/week).; Circulating dendritic cells (DC) were analyzed by flow-cytometry for BDCA-1/-2-expression. TLR-2/-4/-7 and MyD88 were analyzed by RT-PCR and Western blot. Circulating oxLDL levels were analyzed by ELISA.; BDCA-1 expression at baseline was lower in ONE compared to both other groups (ONE 0.15%; LNE 0.27%; LE 0.33%; P < .05), but significantly increased in ONE after training (+50%; P < .05). In contrast, BDCA-2 expression at baseline was higher in ONE (ONE 0.25%; LNE 0.11%; LE 0.09%; P < .05) and decreased in ONE after the 10-week training period (-27%; P < .05). Gene activations of TLR-4 and TLR-7 with corresponding protein increase were found for all three groups (P < .01/P < .05) compared to pre training. A reduction of oxLDL levels was seen in ONE (-61%; P < .05).; Intensified exercise induces an increase of BDCA-1+ DCs and TLR-4/-7 in obese athletes. We hereby describe new immune modulatory effects, which-through regular aerobic exercise-modulate innate immunity and pro-inflammatory cytokines in obesity.
Faculties and Departments:03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit > Bereich Sport- und Bewegungsmedizin > Sportmedizin (Schmidt-Trucksäss)
03 Faculty of Medicine > Departement Sport, Bewegung und Gesundheit > Bereich Sport- und Bewegungsmedizin > Präventive Sportmedizin (Hanssen)
UniBasel Contributors:Schmidt-Trucksäss, Arno and Hanssen, Henner
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Hindawi
ISSN:0962-9351
e-ISSN:1466-1861
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:03 Aug 2020 14:40
Deposited On:27 Feb 2014 15:45

Repository Staff Only: item control page