Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator

Brellier, Florence and Hostettler, Katrin and Hotz, Hans-Rudolf and Ozcakir, Ceyda and Çöloğlu, Sedat A. and Togbe, Dieudonnée and Ryffel, Bernard and Roth, Michael and Chiquet-Ehrismann, Ruth. (2011) Tenascin-C triggers fibrin accumulation by downregulation of tissue plasminogen activator. FEBS Letters, 585 (6). pp. 913-920.

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Official URL: http://edoc.unibas.ch/dok/A6005487

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We explored novel functions of tenascin-C by comparing mouse embryonic fibroblasts (MEFs) proficient or deficient in tenascin-C expression. Transcript profiling analysis identified tissue plasminogen activator (tPA) as the most consistently over-expressed gene in all tenascin-C deficient MEFs. This was confirmed by real-time PCR as well as by protein expression analysis. In agreement with these observations, tenascin-C deficient MEFs had an increased capacity to digest fibrin in situ. Consistently, tenascin-C expression in vivo was found to correlate with fibrin deposition in several diseases associated with tenascin-C overexpression such as fibrosis, asthma and cancer. In conclusion, the present study suggests a new role of tenascin-C as a regulator of the fibrinolytic system.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Pulmonary Cell Research (Roth/Tamm)
UniBasel Contributors:Roth-Chiarello, Michael
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:05 Jan 2017 14:15
Deposited On:27 Feb 2014 15:45

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