Contractile cell forces exerted on rigid substrates

Köser, Joachim and Gaiser, Sebastian and Müller, Bert. (2011) Contractile cell forces exerted on rigid substrates. European cells & materials, Vol. 21 , S. 479-486, discussion 486-487.

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Official URL: http://edoc.unibas.ch/dok/A6004098

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Adhesive cells including fibroblasts produce contractile forces to the underlying substrate for their locomotion. Such forces are not only high enough to deform compliant membranes such as silicone but also bend rigid micro-cantilevers. The cell-induced bending of silicon micro-cantilevers was determined using laser deflection during trypsin treatment. The observed cantilever relaxation corresponds to a contractile cell force of (16±7) µN per rat-2 fibroblast. The cantilever bending approach represents a unique method for the determination of contractile cell forces on any kind of rigid substrate in desired (physiological) environment. Hence, the fundamental technique allows building cell-based biosensors or should provide a quantitative parameter for characterising the cyto-compatibility of load bearing implant surfaces.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedical Engineering > Imaging and Computational Modelling > Biomaterials Science Center (Müller)
UniBasel Contributors:Müller, Bert
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Univ. of Wales
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:27 Feb 2014 15:45
Deposited On:27 Feb 2014 15:45

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