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The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?

Hall, Matthew D. and Ebert, Dieter. (2013) The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated? BMC biology, Vol. 11 , Art. 79.

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Official URL: http://edoc.unibas.ch/dok/A6211991

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Abstract

Interactions amongst genes, known as epistasis, are assumed to make a substantial contribution to the genetic variation in infectious disease susceptibility, but this claim is controversial. Here, we focus on the debate surrounding the evolutionary importance of interactions between resistance loci and argue that its role in explaining overall variance in disease outcomes may have been overestimated.
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Zoologie > Evolutionary Biology (Ebert)
UniBasel Contributors:Ebert, Dieter
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:BioMed Central
ISSN:1741-7007
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:31 Dec 2015 10:54
Deposited On:31 Jan 2014 09:50

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