edoc

Specificity of monosynaptic sensory-motor connections imposed by repellent Sema3E-PlexinD1 signaling

Fukuhara, Kaori and Imai, Fumiyasu and Ladle, David R. and Katayama, Kei-Ichi and Leslie, Jennifer R. and Arber, Silvia and Jessell, Thomas M. and Yoshida, Yutaka. (2013) Specificity of monosynaptic sensory-motor connections imposed by repellent Sema3E-PlexinD1 signaling. Cell reports, Vol. 5, H. 3. pp. 748-758.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6205265

Downloads: Statistics Overview

Abstract

In mammalian spinal cord, group Ia proprioceptive afferents form selective monosynaptic connections with a select group of motor pool targets. The extent to which sensory recognition of motor neurons contributes to the selectivity of sensory-motor connections remains unclear. We show here that proprioceptive sensory afferents that express PlexinD1 avoid forming monosynaptic connections with neurons in Sema3E(+) motor pools yet are able to form direct connections with neurons in Sema3E(off) motor pools. Anatomical and electrophysiological analysis of mice in which Sema3E-PlexinD1 signaling has been deregulated or inactivated genetically reveals that repellent signaling underlies aspects of the specificity of monosynaptic sensory-motor connectivity in these reflex arcs. A semaphorin-based system of motor neuron recognition and repulsion therefore contributes to the formation of specific sensory-motor connections in mammalian spinal cord.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Neurobiology > Cell Biology (Arber)
09 Associated Institutions > Friedrich Miescher Institut FMI
UniBasel Contributors:Arber, Silvia
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:2211-1247
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:18 Jul 2014 09:10
Deposited On:31 Jan 2014 09:49

Repository Staff Only: item control page