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Zinc salts provide a novel, prolonged and rapid inhibition of gastric acid secretion

Kirchhoff, Philipp and Socrates, Thenral and Sidani, Shafik and Duffy, Andrew and Breidthardt, Tobias and Grob, Christian and Viehl, Carsten T. and Beglinger, Christoph and Oertli, Daniel and Geibel, John P.. (2011) Zinc salts provide a novel, prolonged and rapid inhibition of gastric acid secretion. The American journal of gastroenterology, Vol. 106, H. 1. pp. 62-70.

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Official URL: http://edoc.unibas.ch/dok/A6004621

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Abstract

The overproduction of acid and the associated illnesses linked to hypersecretion have a lifetime prevalence of 25-35% in the United States. Although a variety of pharmaceutical agents have been used to reduce the production of acid, alarming new evidence questions the long-term efficacy and safety of the agents. These issues coupled with the delayed onset of action and the return of symptoms in over 60% of the patients is less than satisfactory. The purpose of this study was to determine whether administration of a zinc salt could lead to a rapid and sustained increase in gastric pH in both animals and in humans and provide a new rapid acid suppression therapy.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Former Units at DBM > Gastroenterology (Beglinger)
03 Faculty of Medicine > Bereich Operative Fächer (Klinik) > Innere Organe > Allgemein- und Viszeralchirurgie (Oertli)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Operative Fächer (Klinik) > Innere Organe > Allgemein- und Viszeralchirurgie (Oertli)
UniBasel Contributors:Beglinger, Christoph and Oertli, Daniel and Viehl, Carsten Thomas and Kirchhoff, Philipp
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Blackwell
ISSN:0002-9270
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:06 Dec 2013 09:36
Deposited On:06 Dec 2013 09:36

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