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Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans

Stuehler, Claudia and Khanna, Nina and Bozza, Silvia and Zelante, Teresa and Moretti, Silvia and Kruhm, Michaela and Lurati, Sarah and Conrad, Barbara and Worschech, Eike and Stevanovi?, Stefan and Krappmann, Sven and Einsele, Hermann and Latgé, Jean-Paul and Loeffler, Juergen and Romani, Luigina and Topp, Max S.. (2011) Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans. Blood, Vol. 117, H. 22. pp. 5881-5891.

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Official URL: http://edoc.unibas.ch/dok/A6006023

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Abstract

T cell-mediated heterologous immunity to different pathogens is promising for the development of immunotherapeutic strategies. Aspergillus fumigatus and Candida albicans, the 2 most common fungal pathogens causing severe infections in immunocompromised patients, are controlled by CD4+ type 1 helper T (T(H)1) cells in humans and mice, making induction of fungus-specific CD4+ T(H)1 immunity an appealing strategy for antifungal therapy. We identified an immunogenic epitope of the A fumigatus cell wall glucanase Crf1 that can be presented by 3 common major histocompatibility complex class II alleles and that induces memory CD4+ T(H)1 cells with a diverse T-cell receptor repertoire that is cross-reactive to C albicans. In BALB/c mice, the Crf1 protein also elicits cross-protection against lethal infection with C albicans that is mediated by the same epitope as in humans. These data illustrate the existence of T cell-based cross-protection for the 2 distantly related clinically relevant fungal pathogens that may foster the development of immunotherapeutic strategies.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Infektiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Infektiologie
03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Infection Biology (Khanna)
UniBasel Contributors:Khanna, Nina
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Society of Hematology
ISSN:1528-0020
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 May 2015 08:44
Deposited On:06 Dec 2013 09:36

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