CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients

Baumhoer, Daniel and Elsner, Mareike and Smida, Jan and Zillmer, Stephanie and Rauser, Sandra and Schoene, Cédrik and Balluff, Benjamin and Bielack, Stefan and Jundt, Gernot and Walch, Axel and Nathrath, Michaela. (2011) CRIP1 expression is correlated with a favorable outcome and less metastases in osteosarcoma patients. OncoTarget, Vol. 2, H. 12. pp. 970-975.

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Official URL: http://edoc.unibas.ch/dok/A6004668

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Predicting the clinical course of osteosarcoma patients is a crucial prerequisite for a better treatment stratification in these highly aggressive neoplasms of bone. In search of new and reliable biomarkers we recently identified cysteine-rich intestinal protein 1 (CRIP1) to have significant prognostic impact in gastric cancer and therefore decided to investigate its role also in osteosarcoma. For this purpose we analyzed 223 pretherapeutic and well characterized osteosarcoma samples for their immunohistochemical expression of CRIP1 and correlated our findings with clinico-pathological parameters including follow?up, systemic spread and response to chemotherapy. Interestingly and contrarily to gastric cancer, we found CRIP1 expression more frequently in patients with long?term survival (10-year survival 73% in positive vs. 54% in negative cases, p = 0.0433) and without metastases (p = 0.0108) indicating a favorable prognostic effect. CRIP1 therefore seems to represent a promising new biomarker in osteosarcoma patients which should be considered for a prospective validation.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB
UniBasel Contributors:Jundt, Gernot
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Impact Journals LLC
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:06 Dec 2013 09:35
Deposited On:06 Dec 2013 09:35

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