Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis

van Es, Michael A. and Schelhaas, Helenius J. and van Vught, Paul W. J. and Ticozzi, Nicola and Andersen, Peter M. and Groen, Ewout J. N. and Schulte, Claudia and Blauw, Hylke M. and Koppers, Max and Diekstra, Frank P. and Fumoto, Katsumi and LeClerc, Ashley Lyn and Keagle, Pamela and Bloem, Bastiaan R. and Scheffer, Hans and van Nuenen, Bart F. L. and van Blitterswijk, Marka and van Rheenen, Wouter and Wills, Anne-Marie and Lowe, Patrick P. and Hu, Guo-fu and Yu, Wenhao and Kishikawa, Hiroko and Wu, David and Folkerth, Rebecca D. and Mariani, Claudio and Goldwurm, Stefano and Pezzoli, Gianni and Van Damme, Philip and Lemmens, Robin and Dahlberg, Caroline and Birve, Anna and Fernández-Santiago, Rubén and Waibel, Stefan and Klein, Christine and Weber, Markus and van der Kooi, Anneke J. and de Visser, Marianne and Verbaan, Dagmar and van Hilten, Jacobus J. and Heutink, Peter and Hennekam, Eric A. M. and Cuppen, Edwin and Berg, Daniela and Brown, Robert H. and Silani, Vincenzo and Gasser, Thomas and Ludolph, Albert C. and Robberecht, Wim and Ophoff, Roel A. and Veldink, Jan H. and Pasterkamp, R. Jeroen and de Bakker, Paul I. W. and Landers, John E. and van de Warrenburg, Bart P. and van den Berg, Leonard H.. (2011) Angiogenin variants in Parkinson disease and amyotrophic lateral sclerosis. Annals of neurology, Vol. 70, H. 6. pp. 964-973.

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Official URL: http://edoc.unibas.ch/dok/A6007294

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Abstract

Several studies have suggested an increased frequency of variants in the gene encoding angiogenin (ANG) in patients with amyotrophic lateral sclerosis (ALS). Interestingly, a few ALS patients carrying ANG variants also showed signs of Parkinson disease (PD). Furthermore, relatives of ALS patients have an increased risk to develop PD, and the prevalence of concomitant motor neuron disease in PD is higher than expected based on chance occurrence. We therefore investigated whether ANG variants could predispose to both ALS and PD.

Faculties and Departments:	03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Neurologie 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Neurologie
UniBasel Contributors:	Weber, Markus
Item Type:	Article, refereed
Article Subtype:	Further Journal Contribution
Publisher:	Wiley-Liss
ISSN:	0364-5134
Note:	Publication type according to Uni Basel Research Database: Journal item
Last Modified:	25 Oct 2013 08:32
Deposited On:	25 Oct 2013 08:32

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