Mansi, Rosalba and Wang, Xuejuan and Forrer, Flavio and Waser, Beatrice and Cescato, Renzo and Graham, Keith and Borkowski, Sandra and Reubi, Jean Claude and Maecke, Helmut R.. (2011) Development of a potent DOTA-conjugated bombesin antagonist for targeting GRPr-positive tumours. European journal of nuclear medicine and molecular imaging, Vol. 38, H. 1. pp. 97-107.
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Official URL: http://edoc.unibas.ch/dok/A6004126
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Abstract
Radiolabelled somatostatin-based antagonists show a higher uptake in tumour-bearing mouse models than agonists of similar or even distinctly higher receptor affinity. Very similar results were obtained with another family of G protein-coupled receptor ligands, the bombesin family. We describe a new conjugate, RM2, with the chelator DOTA coupled to D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-Leu-NH(2) via the cationic spacer 4-amino-1-carboxymethyl-piperidine for labelling with radiometals such as (111)In and (68)Ga.
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Radiologie USB > Nuklearmedizin (Wild) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Radiologie USB > Nuklearmedizin (Wild) |
|---|---|
| UniBasel Contributors: | Forrer, Flavio |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Springer |
| ISSN: | 0340-6997 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: | |
| Last Modified: | 25 Oct 2013 08:32 |
| Deposited On: | 25 Oct 2013 08:32 |
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