Urinary and systemic metabolites of prostacyclin in the perfused rabbit kidney

Rosenkranz, B. and Hofbauer, K. and Fischer, C. and Frolich, J. C.. (1982) Urinary and systemic metabolites of prostacyclin in the perfused rabbit kidney. Renal Physiology, Vol. 5, H. 4. pp. 186-191.

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Official URL: http://edoc.unibas.ch/dok/A5258681

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Rabbit kidneys were isolated and perfused with a solution to which tritiated or unlabeled prostacyclin was added continuously. The ureteral and venous effluents were collected separately and chromatographed. The peaks obtained by high-pressure liquid chromatography were analyzed using gas chromatography-mass spectrometry. The characteristic fragments of dinor-6-keto-PGF1 alpha could be detected from ureteral and venous effluents and represented material corresponding to 9.6 and 9.1% of the radioactivity recovered from chromatography, respectively. In addition, 39.2% (ureteral effluent) and 58.2% (renal venous effluent) of the radioactivity could be identified as 6-keto-PGF1 alpha, the stable in vitro hydrolysis product of prostacyclin. These results show that the kidney is able to degrade prostacyclin by beta-oxidation and that dinor-6-keto-PGF1 alpha formed in the kidney can be detected in both the vascular and urinary compartments.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Hofbauer)
UniBasel Contributors:Hofbauer, Karl G.
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:20
Deposited On:22 Mar 2012 13:20

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