Does vasopressin sustain blood pressure of normally hydrated healthy volunteers?

Bussien, J. P. and Waeber, B. and Nussberger, J. and Schaller, M. D. and Gavras, H. and Hofbauer, K. and Brunner, H. R.. (1984) Does vasopressin sustain blood pressure of normally hydrated healthy volunteers? American Journal of Physiology. Heart and Circulatory Physiology, Vol. 246, H. 1 , H143-H147.

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Official URL: http://edoc.unibas.ch/dok/A5258668

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The inhibitor of the pressor effect of arginine vasopressin (AVP), d(CH2)5Tyr(Me)AVP, at a dose of 5 micrograms/kg iv was shown in four healthy volunteers to antagonize the blood pressure, heart rate, and skin blood flow response to a lysine vasopressin infusion of 1 mIU X kg-1 X min-1. The inhibition lasted for more than 2 h. When the same dose of the vasopressin antagonist was administered to 10 healthy normally hydrated volunteers with their renin system intact or acutely blocked by 25 mg of captopril po, none of the above parameters changed. It is concluded that circulating vasopressin, even in the face of a blocked renin-angiotensin system, does not actively contribute to maintenance of cardiovascular homeostasis.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Pharmacology/Neurobiology (Hofbauer)
UniBasel Contributors:Hofbauer, Karl G.
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:American Physiological Society
Note:Publication type according to Uni Basel Research Database: Journal article
Last Modified:22 Mar 2012 14:20
Deposited On:22 Mar 2012 13:20

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