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PCM1-JAK2-fusion : a potential treatment target in myelodysplastic-myeloproliferative and other hemato-lymphoid neoplasms

Hoeller, Sylvia and Walz, Christoph and Reiter, Andreas and Dirnhofer, Stephan and Tzankov, Alexandar. (2011) PCM1-JAK2-fusion : a potential treatment target in myelodysplastic-myeloproliferative and other hemato-lymphoid neoplasms. Expert opinion on therapeutic targets, Vol. 15, H. 1. pp. 53-62.

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Official URL: http://edoc.unibas.ch/dok/A6006844

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Abstract

Activating mutations of the JAK2 gene are of tumorigenic significance in myeloproliferative neoplasms. Translocations involving the JAK2 locus are of oncogenic importance in acute leukemias, myelodysplastic/myeloproliferative diseases and T-cell lymphomas. JAK2 locus gains, which are recurrent in Hodgkin's- and primary mediastinal B-cell lymphoma, are also efficient mechanisms of JAK2 activation. Recently, specific drugs blocking JAK2 have been developed and are currently in clinical trials.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Histopathologie (Dirnhofer)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Histopathologie (Dirnhofer)
UniBasel Contributors:Dirnhofer, Stephan and Tzankov, Alexandar
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Informa Healthcare
ISSN:1472-8222
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Sep 2013 07:59
Deposited On:13 Sep 2013 07:57

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