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Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis

Waschbisch, Anne and Atiya, Monika and Linker, Ralf A. and Potapov, Sergej and Schwab, Stefan and Derfuss, Tobias. (2011) Glatiramer acetate treatment normalizes deregulated microRNA expression in relapsing remitting multiple sclerosis. PLoS ONE, Vol. 6, H. 9 , e24604.

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Official URL: http://edoc.unibas.ch/dok/A6004661

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Abstract

The expression of selected microRNAs (miRNAs) known to be involved in the regulation of immune responses was analyzed in 74 patients with relapsing remitting multiple sclerosis (RRMS) and 32 healthy controls. Four miRNAs (miR-326, miR-155, miR-146a, miR-142-3p) were aberrantly expressed in peripheral blood mononuclear cells from RRMS patients compared to controls. Although expression of these selected miRNAs did not differ between treatment-naïve (n?=?36) and interferon-beta treated RRMS patients (n?=?18), expression of miR-146a and miR-142-3p was significantly lower in glatiramer acetate (GA) treated RRMS patients (n?=?20) suggesting that GA, at least in part, restores the expression of deregulated miRNAs in MS.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Clinical Neuroimmunology (Derfuss/Lindberg)
03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Neurologie > Molekulare Neuroimmunologie (Derfuss)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Neurologie > Molekulare Neuroimmunologie (Derfuss)
UniBasel Contributors:Derfuss, Tobias Johannes
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Public Library of Science
e-ISSN:1932-6203
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:31 Aug 2018 06:40
Deposited On:13 Sep 2013 07:57

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