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Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism

Young, Barry P. and Shin, John J. H. and Orij, Rick and Chao, Jesse T. and Li, Shu Chen and Guan, Xue Li and Khong, Anthony and Jan, Eric and Wenk, Markus R. and Prinz, William A. and Smits, Gertien J. and Loewen, Christopher J. R.. (2010) Phosphatidic acid is a pH biosensor that links membrane biogenesis to metabolism. Science, Vol. 329, H. 5995. pp. 1085-1088.

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Official URL: http://edoc.unibas.ch/dok/A6165291

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Abstract

Recognition of lipids by proteins is important for their targeting and activation in many signaling pathways, but the mechanisms that regulate such interactions are largely unknown. Here, we found that binding of proteins to the ubiquitous signaling lipid phosphatidic acid (PA) depended on intracellular pH and the protonation state of its phosphate headgroup. In yeast, a rapid decrease in intracellular pH in response to glucose starvation regulated binding of PA to a transcription factor, Opi1, that coordinately repressed phospholipid metabolic genes. This enabled coupling of membrane biogenesis to nutrient availability.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Molecular Immunology (Pluschke)
UniBasel Contributors:Guan, Xueli and Wenk, Markus
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:American Association for the Advancement of Science
ISSN:0036-8075
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:13 Sep 2013 07:59
Deposited On:13 Sep 2013 07:53

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