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The influence of clinical risk factors on pre-operative B-type natriuretic peptide risk stratification of vascular surgical patients

Biccard, B. M. and Lurati Buse, G. A. and Burkhart, C. and Cuthbertson, B. H. and Filipovic, M. and Gibson, S. C. and Mahla, E. and Leibowitz, D. W. and Rodseth, R. N.. (2012) The influence of clinical risk factors on pre-operative B-type natriuretic peptide risk stratification of vascular surgical patients. Anaesthesia, Vol. 67, H. 1. pp. 55-59.

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Official URL: http://edoc.unibas.ch/dok/A6007756

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Abstract

The role of the revised cardiac risk index in risk stratification has recently been challenged by studies reporting on the superior predictive ability of pre-operative B-type natriuretic peptides. We found that in 850 vascular surgical patients initially risk stratified using B-type natriuretic peptides, reclassification with the number of revised cardiac risk index risk factors worsened risk stratification (p?>?0.05 for <?0, <?2, <?3 and <?4 risk factors, and p?=?0.23 for <?1 risk factor). When evaluated with pre-operative B-type natriuretic peptides, none of the revised cardiac risk index risk factors were independent predictors of major adverse cardiac events in vascular patients. The only independent predictor was B-type natriuretic peptide stratification (OR 5.1, 95% CI 1.8-15 for the intermediate class, and OR 25, 95% CI 8.7-70 for the high-risk class). The clinical risk factors in the revised cardiac risk index cannot improve a risk stratification model based on B-type natriuretic peptides.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Anästhesiologie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Anästhesiologie
UniBasel Contributors:Filipovic, Miodrag
Item Type:Article, refereed
Article Subtype:Further Journal Contribution
Bibsysno:Link to catalogue
Publisher:Pulman
ISSN:0003-2409
Note:Publication type according to Uni Basel Research Database: Journal item
Last Modified:13 Sep 2013 07:59
Deposited On:13 Sep 2013 07:50

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