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Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection

Haas, Anna and Zimmermann, Kathrin and Graw, Frederik and Slack, Emma and Rusert, Peter and Ledergerber, Bruno and Bossart, Walter and Weber, Rainer and Thurnheer, Maria C. and Battegay, Manuel and Hirschel, Bernard and Vernazza, Pietro and Patuto, Nicola and Macpherson, Andrew J. and Günthard, Huldrych F. and Oxenius, Annette and Swiss HIV Cohort Study, . (2011) Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection. Gut, Vol. 60, H. 11. pp. 1506-1519.

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Official URL: http://edoc.unibas.ch/dok/A6004090

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Abstract

Human systemic antibody responses to commensal microbiota are not well characterised during health and disease. Of particular interest is the analysis of their potential modulation caused by chronic HIV-1 infection which is associated with sustained enteropathy and systemic B cell disturbances reflected by impaired B cell responses and chronic B cell hyperactivity. The mechanisms underlying B cell hyperactivation and the specificities of the resulting hypergammaglobulinaemia are only poorly understood.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Infection Biology (Khanna)
UniBasel Contributors:Battegay, Manuel E.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:British Medical Association
ISSN:0017-5749
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:16 Aug 2013 07:34
Deposited On:16 Aug 2013 07:32

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