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Genome-wide association analyses identify 18 new loci associated with serum urate concentrations

Köttgen, A. and Albrecht, E. and Teumer, A. and Vitart, V. and Krumsiek, J. and Hundertmark, C. and Pistis, G. and Ruggiero, D. and O'Seaghdha, C. M. and Haller, T. and Yang, Q. and Tanaka, T. and Johnson, A. D. and Kutalik, Z. and Smith, A. V. and Shi, J. and Struchalin, M. and Middelberg, R. P. and Brown, M. J. and Gaffo, A. L. and Pirastu, N. and Li, G. and Hayward, C. and Zemunik, T. and Huffman, J. and Yengo, L. and Zhao, J. H. and Demirkan, A. and Feitosa, M. F. and Liu, X. and Malerba, G. and Lopez, L. M. and van der Harst, P. and Li, X. and Kleber, M. E. and Hicks, A. A. and Nolte, I. M. and Johansson, A. and Murgia, F. and Wild, S. H. and Bakker, S. J. and Peden, J. F. and Dehghan, A. and Steri, M. and Tenesa, A. and Lagou, V. and Salo, P. and Mangino, M. and Rose, L. M. and Lehtimaki, T. and Woodward, O. M. and Okada, Y. and Tin, A. and Muller, C. and Oldmeadow, C. and Putku, M. and Czamara, D. and Kraft, P. and Frogheri, L. and Thun, G. A. and Grotevendt, A. and Gislason, G. K. and Harris, T. B. and Launer, L. J. and McArdle, P. and Shuldiner, A. R. and Boerwinkle, E. and Coresh, J. and Schmidt, H. and Schallert, M. and Martin, N. G. and Montgomery, G. W. and Kubo, M. and Nakamura, Y. and Tanaka, T. and Munroe, P. B. and Samani, N. J. and Jacobs, DR Jr and Liu, K. and D'Adamo, P. and Ulivi, S. and Rotter, J. I. and Psaty, B. M. and Vollenweider, P. and Waeber, G. and Campbell, S. and Devuyst, O. and Navarro, P. and Kolcic, I. and Hastie, N. and Balkau, B. and Froguel, P. and Esko, T. and Salumets, A. and Khaw, K.. (2013) Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature genetics, Vol. 45, H. 2. pp. 145-154.

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Official URL: http://edoc.unibas.ch/dok/A6094190

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Abstract

Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from <140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology
UniBasel Contributors:Probst Hensch, Nicole
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Nature Publ
ISSN:1061-4036
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:16 Aug 2013 07:34
Deposited On:16 Aug 2013 07:32

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