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Regulation of Fas mediated apoptosis by CD44

Mielgo Iza, Ainhoa. Regulation of Fas mediated apoptosis by CD44. 2005, Doctoral Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_7218

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Abstract

Over the last decade, apoptosis has grown from an obscure process to a complex and
interesting scientific field, and many players have been identified. One of the basic
features of malignant transformation and autoimmunity is the acquisition of resistance to
apoptosis. Many reports suggest that CD44 variant isoforms exhibit an anti-apoptotic
effect leading to the progression of cancer and inflammatory diseases. However the
molecular mechanisms of CD44s and CD44v actions have so far not been elucidated.
Moreover literature about CD44 is controversial, some researchers describe CD44 as a
survival molecule, others as a pro-apoptotic protein. Probably, this controversy is due to
the presence of several isoforms and it might be possible that isoforms exhibit different
and/or even opposite functions.
The aims of this study were to elucidate the following questions:
1) Are CD44 standard and/or variant isoforms regulating Fas-mediated apoptosis
and how? (Chapter I and II).
2) Which is the in vivo implication of CD44 variant isoforms in autoimmune
diseases such as multiple sclerosis and experimental autoimmune
encephalomyelitis? (Chapter III).
To find an answer to these questions will improve our understanding of the pathogenesis
of life threatening diseases such as cancer and autoimmunity, and may open new
treatment strategies.
Advisors:Rolink, Antonius G.
Committee Members:Erb, Peter and Günthert, Ursula
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Further Research Groups at DBM > Developmental and Molecular Immunology (Rolink)
UniBasel Contributors:Rolink, Antonius G. and Günthert, Ursula
Item Type:Thesis
Thesis Subtype:Doctoral Thesis
Thesis no:7218
Thesis status:Complete
Bibsysno:Link to catalogue
Number of Pages:119
Language:English
Identification Number:
Last Modified:22 Apr 2018 04:30
Deposited On:13 Feb 2009 15:14

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