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Psychobiological responses to drug cues before and after methadone intake in heroin-dependent patients : a pilot study

Walter, M. and Wiesbeck, G. A. and Bloch, N. and Aeschbach, S. and Olbrich, H. M. and Seifritz, E. and Dürsteler-MacFarland, K. M.. (2008) Psychobiological responses to drug cues before and after methadone intake in heroin-dependent patients : a pilot study. European neuropsychopharmacology, Vol. 18, H. 5. pp. 390-393.

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Official URL: http://edoc.unibas.ch/dok/A6003187

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Abstract

Craving and stress frequently drive compulsive heroin use. Although methadone attenuates craving, drug-conditioned stimuli can trigger craving and possibly stress arousal in heroin-dependent patients receiving methadone maintenance. This study investigated drug cue-related craving, affectivity, and cortisol reactivity in 16 methadone-maintained patients before and after daily methadone. Unexpectedly, drug cues significantly increased craving after (t[15]=-4.27, p=0.001), but not before methadone intake. Patients displayed blunted cortisol response after post-methadone drug cues (t[15]=3.05, p=0.008) suggesting dissociated craving and cortisol reactivity after methadone intake of possible clinical relevance.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Lang)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Lang)
UniBasel Contributors:Wiesbeck, Gerhard A. and Walter, Marc
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier Science
ISSN:0924-977X
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Jul 2013 07:43
Deposited On:19 Jul 2013 07:36

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