edoc

Wnt/ -catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4

Fujimori, Sayumi and Novak, Hermann and Weissenböck, Martina and Jussila, Maria and Gonçalves, Alexandre and Zeller, Rolf and Galloway, Jenna and Thesleff, Irma and Hartmann, Christine. (2010) Wnt/ -catenin signaling in the dental mesenchyme regulates incisor development by regulating Bmp4. Developmental biology, Vol. 348. pp. 97-106.

Full text not available from this repository.

Official URL: http://edoc.unibas.ch/dok/A6006847

Downloads: Statistics Overview

Abstract

Loss- and gain-of function approaches modulating canonical Wnt/ -catenin activity have established a role for the Wnt/ -catenin pathway during tooth development. Here we show that Wnt/ -catenin signaling is required in the dental mesenchyme for normal incisor development, as locally restricted genetic inactivation of -catenin results in a splitting of the incisor placode, giving rise to two incisors. Molecularly this is first associated with down-regulation of Bmp4 and subsequent splitting of the Shh domain at a subsequent stage. The latter phenotype can be mimicked by ectopic application of the BMP antagonist Noggin. Conditional genetic inactivation of Bmp4 in the mesenchyme reveals that mesenchymal BMP4 activity is required for maintenance of Shh expression in the dental ectoderm. Taken together our results indicate that -catenin together with Lef1 and Tcf1 are required to activate Bmp4 expression in order to maintain Shh expression in the dental ectoderm. This provides a mechanism whereby the number of incisors arising from one placode can be varied through local alterations of a mesenchymal signaling circuit involving -catenin, Lef1, Tcf1 and Bmp4.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Anatomy > Developmental Genetics (Zeller/Zuniga)
UniBasel Contributors:Zeller, Rolf
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Academic Press
ISSN:1095-564X
Note:Publication type according to Uni Basel Research Database: Journal article
Related URLs:
Identification Number:
Last Modified:19 Jul 2013 07:43
Deposited On:19 Jul 2013 07:35

Repository Staff Only: item control page