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Vascular endothelial growth factor-related pathways in hemato-lymphoid malignancies

Medinger, Michael and Fischer, Natalie and Tzankov, Alexandar. (2010) Vascular endothelial growth factor-related pathways in hemato-lymphoid malignancies. Journal of Oncology (729725).

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Official URL: http://edoc.unibas.ch/dok/A6003779

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Abstract

Angiogenesis is essential for malignant tumor growth. This has been documented for solid tumors, and there is an emerging evidence suggesting that tumor progression of hematolymphoid malignancies also depends on the induction of new blood vessel formation. The most important proangiogenic agent is vascular endothelial growth factor (VEGF), activating VEGF receptors 1 and 2. The available data on angiogenesis in hemato-lymphoid malignancies, such as acute leukemias, myelodysplastic syndromes, myeloproliferative neoplasms, multiple myeloma, and lymphomas, point towards the significance of autocrine and paracrine VEGF-mediated effects for proliferation and survival of leukemia/lymphoma cells in addition to tumor vascularization. Antiangiogenic strategies have become an important therapeutic modality for solid tumors. Several antiangiogenic agents targeting VEGF-related pathways are also being utilized in clinical trials for the treatment of hemato-lymphoid malignancies, and in some instances these pathways have emerged as promising therapeutic targets. This review summarizes recent advances in the basic understanding of the role of angiogenesis in hemato-lymphoid malignancies and the translation of such basic findings into clinical studies.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Histopathologie (Dirnhofer)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Pathologie USB > Histopathologie (Dirnhofer)
03 Faculty of Medicine
UniBasel Contributors:Tzankov, Alexandar and Medinger, Michael
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Hindawi Publishing Corporation
ISSN:1687-8450
e-ISSN:1687-8469
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Oct 2017 09:58
Deposited On:21 Jun 2013 12:26

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