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The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype : a cohort study of 95 patients with autoimmune thyroid disorders

Potlukova, Eliska and Jiskra, Jan and Freiberger, Tomas and Limanova, Zdenka and Zivorova, Dana and Malickova, Karin and Springer, Drahomira and Grodecka, Lucie and Antosova, Marie and Telicka, Zdenek and Pesickova, Satu Sinikka and Trendelenburg, Marten. (2010) The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype : a cohort study of 95 patients with autoimmune thyroid disorders. Clinical immunology, Vol. 136, H. 1. pp. 123-129.

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Official URL: http://edoc.unibas.ch/dok/A6003554

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Abstract

Complement mannan-binding lectin (MBL) deficiency is associated with increased susceptibility to infections and autoimmune diseases. Previous studies suggested that the production of MBL is stimulated by thyroid hormones. The aim of our study was to investigate this association in patients with autoimmune thyroid diseases (AITD). Serum levels of MBL and parameters of the thyroid function were determined in 62 patients with Hashimoto's thyroiditis, 33 with Graves' disease and 47 blood donors. Follow-up measurements were performed after 6 to 24 months. MBL2 genotypes were determined using multiplex PCR and compared to 359 healthy Czech individuals. Serum levels of MBL tightly correlated with thyroid hormones, leading to strongly increased MBL levels in hyperthyroidism and decreased levels in hypothyroidism. With normalization of the thyroid function during follow-up, MBL levels decreased or increased respectively. The observed correlations were not due to MBL polymorphisms since the frequency of MBL2 polymorphisms in AITD patients was not different from the general population. We conclude that AITD are not associated with MBL polymorphisms. However, the MBL production is strongly dependent on thyroid function, regardless of the genotype.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Clinical Immunology (Trendelenburg)
UniBasel Contributors:Trendelenburg, Marten
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1090-2341
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:21 Jun 2013 12:29
Deposited On:21 Jun 2013 12:25

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